You can change to a dynamic volume and then extend that volume onto the second disk (called a 'spanned volume'). This has some pretty serious consequences -- if either disk fails, your system is completely hosed.
I would not recommend doing this.
Buy a new drive, use a free tool to migrate your primary over to that drive, and use the new, larger drive.
If you must use both drives, I would do the following:
1) Uninstall a couple of large applications.
2) Reinstall them onto the other drive. If you use 'expert' mode, most applications will let you choose where to install them.
Edit: Ariyle55 is wrong. Vista editions either support dynamic drives for all partitions or none. There is no version of Vista that supports dynamic drives at all that won't let you extend your system partition. His answer would be correct for XP, which this isn't.
Oh, and in case he reads this: 1) You should check your facts before you tell someone else that they are wrong. 2) You should enable emails so that people can warn you when you are spreading misinformation.